Platelet Rich Fibrin In Regenerative Dentistry.
From Biological Background to Clinical Applications.

The use of platelet concentrates has had a long-history of use in various fields of medicine as an autologous source of growth factors fabricated utilizing centrifugation of blood under various conditions. While platelet rich plasma (PRP) was proposed as a first-generation platelet concentrate over 3 decades ago, over the past 10 years, platelet rich fibrin (PRF) has seen a steady increase in utilization for a variety of medical procedures due to its lack of anti-coagulation factors favoring fibrin clot formation and faster wound healing. More recently, further research has demonstrated that shorter and slower centrifugation spin cycles (‘the low speed concept’) additionally favors wound healing by incorporating higher populations of white blood cells and progenitor cells within the PRF fibrin matrix leading to higher growth factor release within the local micro-environment. Parallel to these findings, the development of a liquid PRF provides a new formulation of liquid PRF without using anti-coagulation factors that may specifically be combined with currently available bone biomaterials favoring particle stability, angiogenesis and tissue integration. This course aims to highlight the recent advancements made with respect to the newest formulations of platelet concentrates and systematically presents when, where and why specific platelet concentrates may be utilized to further speed wound healing and tissue regeneration for various clinical indications faced in routine daily dental practice.


Course Objectives:

  • Provide the biological background and scientific rationale for why platelet concentrates speed wound healing;
  • Introduce the low speed centrifugation concept and the theory behind these PRF formulations;
  • Provide clinical indications when, where and why to use PRF (membranes and liquid) in regenerative dentistry;
  • Provide key areas into future uses of PRF for everyday dental practice.


Course Program:



  • Platelet Rich Fibrin intensive course
  • Growth factors: biology and physiology, mechanisms of action
  • Low Speed Centrifugation Concept for PRF: More cytokines and growth factors
  • Composition and influence on tissue healing



  • Use of PRF in oral surgery and periodontology
  • Liquid PRF: PRF that may be injected or combined with biomaterials
  • PRF as a “matrix” in soft tissue management: protocols, clinical results
  • PRF as a “matrix” in bone augmentation: protocols, clinical results



  • Protocols, clinical results, new perspectives in soft tissue regeneration and bone reconstruction
  • PRF mixed with biomaterials: what kind of biomaterials do we have to mix with PRF?



  • In order to maximize the potential of the PRF, blood collection from your patient is necessary.
  • There will be an introductory course in phlebotomy, including a hands-on session.


Mentor: Dr. Richard Miron, DDS, BMSC, MSC, PH
He is currently working within the Department of Periodontology at the University of Southern California in Los Angeles. He is also an Adjunct Visiting Faculty in the department of Periodontology in Bern, Switzerland where he completed his PhD studies since 2009. He has currently published over 150 peer-reviewed articles and lectures internationally on many topics relating to growth factors, bone biomaterials and guided bone regeneration.
Date: Oct 11, 2018
Time: 8:30 – 5pm
Venue: Dental center Rocabella 1059 Mountain Street Suite 207 Montreal, QC H3G 0B9 
Price: $500 CAD (Use code Hiossen for 10% discount)
Instructor: Dr. Richard Miron, DDS, BMSC, MSC, PHD
Registration: Robert Archambault | | 514 358 7134